Del(7Herc2-Mkrn3)13FRdni
Transgenic Allele Detail

Summary

• Symbol: Del(7Herc2-Mkrn3)13FRdni
• Name: deletion, Chr 7, R D Nicholls13F; deletion, Chr 7, R D Nicholls 13F
• MGI ID: MGI:3769770
• Synonyms: Del13FRdni, Tg^PWS/AS(del)
• Gene: Del(7Herc2-Mkrn3)13FRdni Location: Chr7:55699944-62069887 bp Genetic Position: Chr7, Syntenic

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(7Herc2-Mkrn3)13FRdni involves 283 genes/genome features (Gm23490, Gm22466, Gm23873 ...) View all
• Mutation details: Transgene insertion of Tg(Igh-Lmp2a)13FRdni (MGI:3769767) resulted in a 5Mb deletion covering the entire Prader-Willi syndrom homology region. (J:56614, J:103338)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(7Herc2-Mkrn3)13FRdni Mutation: 0 strains or lines available

Notes

This deletion was generated in mice carrying Tg(Igh-Lmp2a)13FRdni. 9 lines were created with the eight others exhibiting lymphocyte cell lineage defects. Line 13F results in a deletion in chromosome 7 from Mkrn3 to Herc2 (Mkrn3, Ndn, Snurf/Snrpn, Ube3a, and Herc2 are deleted).

References

• Original: J:56614 Gabriel JM, et al., A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9258-63
• All: 7 reference(s)