Tg(IGFBP1)2Miel
Transgene Detail

Summary

• Symbol: Tg(IGFBP1)2Miel
• Name: transgene insertion 2, John Miell
• MGI ID: MGI:3769998
• Synonyms: c1:2-2, hIGFBP-1 (line c1:2-2)
• Transgene: Tg(IGFBP1)2Miel Location: unknown
• Alliance: Tg(IGFBP1)2Miel page

Placental morphology and histology indicates differences in trophoblast invasion and differentiation in Tg(IGFBP1)2Miel/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL and CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(IGFBP1)2Miel expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGFBP1 (3484)

  Igfbp1

  (MGI:96436)

• Mutation details: The hIGFBP-1 transgene (isolated from a human cosmid clone) contains the entire structural IGFBP1 gene and all the cis acting sequences necessary to direct appropriate tissue-specific and regulated gene expression. Founder mice (line c1:2-2) were bred to CBA/Ca and the transgene copy number was found to be between 8 and 20. (J:128964)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128964 Crossey PA, et al., Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance. Diabetes. 2000 Mar;49(3):457-65
• All: 5 reference(s)