Csrnp3^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Csrnp3^tm1Jni
• Name: cysteine-serine-rich nuclear protein 3; targeted mutation 1, James N Ihle
• MGI ID: MGI:3770132
• Synonyms: CSRNP-3^-
• Gene: Csrnp3 Location: Chr2:65676111-65861890 bp, + strand Genetic Position: Chr2, 38.79 cM
• Alliance: Csrnp3^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129366
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 and part of 6 were replaced with a neo cassette. The lack of protein product was confirmed by western blot analysis on brain extracts. (J:129366)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Csrnp3^tm1Jni/Csrnp3^tm1Jni	involves: 129P2/OlaHsd * C57BL/6
cx2	Csrnp3^tm1Jni/Csrnp3^tm1Jni Csrnp1^tm1Jni/Csrnp1^+ Csrnp2^tm1Jni/Csrnp2^tm1Jni	involves: 129P2/OlaHsd * C57BL/6
cx3	Csrnp3^tm1Jni/Csrnp3^tm1Jni Csrnp2^tm1Jni/Csrnp2^tm1Jni	involves: 129P2/OlaHsd * C57BL/6
cx4	Csrnp3^tm1Jni/Csrnp3^tm1Jni Csrnp1^tm1Jni/Csrnp1^tm1Jni Csrnp2^tm1Jni/Csrnp2^tm1Jni	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1	cx2	cx3	cx4
show or hide all annotated terms
embryo	N
embryo phenotype	N
hematopoietic system	N
hematopoietic system phenotype	N
immune system	N
immune system phenotype	N
mortality/aging		√	√	√
postnatal lethality				√
postnatal lethality, incomplete penetrance		√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csrnp3 Mutation: 32 strains or lines available

References

• Original: J:129366 Gingras S, et al., Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). PLoS One. 2007;2(8):e808
• All: 1 reference(s)