Slc4a3^tm1Ges
Targeted Allele Detail

Summary

• Symbol: Slc4a3^tm1Ges
• Name: solute carrier family 4 (anion exchanger), member 3; targeted mutation 1, Gary E Shull
• MGI ID: MGI:3770133
• Synonyms: AE3^-
• Gene: Slc4a3 Location: Chr1:75522688-75536075 bp, + strand Genetic Position: Chr1, 39.16 cM, cytoband C3
• Alliance: Slc4a3^tm1Ges page

Retinal abnormalities in the Slc4a3^tm1Ges/Slc4a3^tm1Ges mouse

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129363
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacing most of exon 6, intron 6, the cardiac-specific first exon and promoter, and exon 7 with a neomycin resistance gene. Expression of both the cardiac specific- short isoform and the long isoform of the gene were eliminated in homozygote mice as determined by western blots of retinal extracts. (J:129363, J:143125)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a3 Mutation: 42 strains or lines available

References

• Original: J:129363 Alvarez BV, et al., Blindness caused by deficiency in AE3 chloride/bicarbonate exchanger. PLoS One. 2007;2(9):e839
• All: 6 reference(s)