Casp14^tm1Wdec
Targeted Allele Detail

Summary

• Symbol: Casp14^tm1Wdec
• Name: caspase 14; targeted mutation 1, Wim Declercq
• MGI ID: MGI:3770173
• Synonyms: Casp14^-, caspase-14^-
• Gene: Casp14 Location: Chr10:78547825-78554128 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Casp14^tm1Wdec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129490
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neo cassette to create a null allele. The absence of protein product was confirmed by western blot analysis. (J:129490)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp14 Mutation: 14 strains or lines available

References

• Original: J:129490 Denecker G, et al., Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol. 2007 Jun;9(6):666-74
• All: 7 reference(s)