Chrm3^tm2Jwe
Targeted Allele Detail

Summary

• Symbol: Chrm3^tm2Jwe
• Name: cholinergic receptor, muscarinic 3, cardiac; targeted mutation 2, Jurgen Wess
• MGI ID: MGI:3770175
• Synonyms: Chrm3^flox, M3R^fl
• Gene: Chrm3 Location: Chr13:9925522-10410883 bp, - strand Genetic Position: Chr13, 3.72 cM
• Alliance: Chrm3^tm2Jwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129643
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of the coding region and an additional loxP site was inserted upstream of the coding region. (J:129643)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm3 Mutation: 51 strains or lines available

References

• Original: J:129643 Gautam D, et al., A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab. 2006 Jun;3(6):449-61
• All: 8 reference(s)