Tln1^tm4.1Crit
Targeted Allele Detail

Summary

• Symbol: Tln1^tm4.1Crit
• Name: talin 1; targeted mutation 4.1, David R Critchley
• MGI ID: MGI:3770513
• Synonyms: Tln1^fl
• Gene: Tln1 Location: Chr4:43531513-43562583 bp, - strand Genetic Position: Chr4, 23.05 cM
• Alliance: Tln1^tm4.1Crit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129707
• Parent Cell Line: E14.1a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Coding exons one through four (second through fifth exons) are flanked by loxP sites. This allele was generated by in vivo, Cre recombinase-mediated deletion of a loxP-flanked neomycin resistance cassette from the first intron of Tln1^tm4Crit in cre transgenic embryos homozygous for the latter allele (personal communication). Talin expression can be ablated in specific cell/tissue types by crossing homozygous mice with appropriate cre transgenic mice. (J:129707)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tln1 Mutation: 147 strains or lines available

References

• Original: J:129707 Petrich BG, et al., Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med. 2007 Dec 24;204(13):3103-11
• All: 45 reference(s)