Lepr^db-9J
Spontaneous Allele Detail

Summary

• Symbol: Lepr^db-9J
• Name: leptin receptor; diabetes 9 Jackson
• MGI ID: MGI:3770610
• Synonyms: fuldib
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^db-9J page

Mutation origin

• Strain of Origin: mixed

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This mutation was shown to be an allele of the leptin receptor gene by its failure to complement the original diabetes mutation, Lepr^db.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

Notes

This mutation arose spontaneously in mice of a mixed genetic background (~46% C57BL/6, ~50% SWR, and ~3% CBA estimated from the breeding records).

References

• Original: J:129982 Naggert JK, et al., A new spontaneous obesity mutation, fuldib/diabetes 9 Jackson, is a allele of the leptin receptor gene. MGI Direct Data Submission. 2008
• All: 1 reference(s)