Tg(tetO-TAg)1Efr
Transgene Detail

Summary

• Symbol: Tg(tetO-TAg)1Efr
• Name: transgene insertion 1, Shimon Efrat
• MGI ID: MGI:3770670
• Synonyms: tet-TAg
• Transgene: Tg(tetO-TAg)1Efr Location: unknown
• Alliance: Tg(tetO-TAg)1Efr page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: To generate the transgene, a fragment containing a tandem array of 7 copies of the tetracycline operator sequence and a cytomegalovirus minimal promoter was placed in front of the SV40 large T antigen gene. The promoter does not allow expression of the TAg gene, and transgenic mice do not develop tumors, unless crossed with mice expressing a tetracycline transactivator gene (tTA or rtTA). (J:56326)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:56326 Efrat S, et al., Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3576-80
• All: 7 reference(s)