Sec14l2^tm1Arai
Targeted Allele Detail

Summary

• Symbol: Sec14l2^tm1Arai
• Name: SEC14-like lipid binding 2; targeted mutation 1, Hiroyuki Arai
• MGI ID: MGI:3771069
• Synonyms: Spf^-
• Gene: Sec14l2 Location: Chr11:4047039-4068729 bp, - strand Genetic Position: Chr11, 2.87 cM, cytoband A1
• Alliance: Sec14l2^tm1Arai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129749
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on hepatic extracts. (J:129749)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sec14l2 Mutation: 28 strains or lines available

References

• Original: J:129749 Shibata N, et al., Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. FASEB J. 2006 Dec;20(14):2642-4
• All: 1 reference(s)