Slc31a1^tm2Djt
Targeted Allele Detail

Summary

• Symbol: Slc31a1^tm2Djt
• Name: solute carrier family 31, member 1; targeted mutation 2, Dennis J Thiele
• MGI ID: MGI:3771147
• Synonyms: Ctr1^flox
• Gene: Slc31a1 Location: Chr4:62278964-62310006 bp, + strand Genetic Position: Chr4, 33.11 cM, cytoband C1-C2
• Alliance: Slc31a1^tm2Djt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129741
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 4 and an additional loxP site was inserted upstream of exon 1. The neo cassette was removed by cre-mediated recombination. (J:129741)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc31a1 Mutation: 40 strains or lines available

References

• Original: J:129741 Nose Y, et al., Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. Cell Metab. 2006 Sep;4(3):235-44
• All: 13 reference(s)