Tg(HIV)26Aln
Transgene Detail

Summary

• Symbol: Tg(HIV)26Aln
• Name: transgene insertion 26, Abner Louis Notkins
• MGI ID: MGI:3771187
• Synonyms: AIDS Tg, T26, Tg26, Tg26^HIV, TgFVB, TgN(pNL43d14), TgN(pNL43d14)26Lom 26
• Transgene: Tg(HIV)26Aln Location: unknown
• Alliance: Tg(HIV)26Aln page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A noninfectious provirus transgene was engineered from an infectious clone of an integrated HIV virus (pNL4-3) by deleting 3.1 kb of sequence between the Sphl site at base position 1443 and the Ball site at position 4551 (Fig. 1A). The in-frame deletion of gag and pol sequences encompasses the coding sequences for p24, p15, protease, reverse transcriptase, and the amino-terminus of p34 endonuclease. This construct, designated pEVdl443, expressed HIV-1 envelope glycoproteins and Tat protein and encodes the regulatory gene products Nef and Rev, as well as Vpu, Vpr, Vif, and a pl7/p34 fusion gene product. In addition to transgenic line 26, lines 22c and 25 were also established. (J:90297)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:90297 Dickie P, et al., HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology. 1991 Nov;185(1):109-19
• All: 52 reference(s)