Hpgdtm1Ljm
Targeted Allele Detail
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Symbol: |
Hpgdtm1Ljm |
Name: |
hydroxyprostaglandin dehydrogenase 15 (NAD); targeted mutation 1, Louis J Muglia |
MGI ID: |
MGI:3771208 |
Synonyms: |
HpgdH |
Gene: |
Hpgd Location: Chr8:56747620-56774078 bp, + strand Genetic Position: Chr8, 29.7 cM, cytoband B3.2
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Alliance: |
Hpgdtm1Ljm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:130001
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Hypomorph) |
Mutation: |
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Insertion
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Mutation details: In the process of creating a loxP-flanked allele, a tandem duplication of exon 1 and 2 with an frt-flanked neo cassete and a 5' loxP site inserted into intron 2 was knocked into the gene. The authors state that this allele is hypomorphic. Northern blot analysis confirmed reduced transcript levels in the lungs and the absence of transcript in the liver and placenta of E17.5 embryos. Enzymatic assays confirmed decreased activity in the adult lungs, liver and E15.5 placenta.
(J:130001)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hpgd Mutation: |
24 strains or lines available
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Original: |
J:130001 Roizen JD, et al., Preterm Birth without Progesterone Withdrawal in 15-Hydroxyprostaglandin Dehydrogenase Hypomorphic Mice. Mol Endocrinol. 2008 Jan;22(1):105-12 |
All: |
1 reference(s) |
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