Gsk3a^tm1Jrw
Targeted Allele Detail

Summary

• Symbol: Gsk3a^tm1Jrw
• Name: glycogen synthase kinase 3 alpha; targeted mutation 1, James R Woodgett
• MGI ID: MGI:3771221
• Synonyms: GSK3alpha^fl, GSK-3alpha flx
• Gene: Gsk3a Location: Chr7:24927683-24937276 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Gsk3a^tm1Jrw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130033
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an frt-flanked and floxed neo cassette was inserted into intron 2. (J:130033)

Tumor Data

List all tumor models in MMHCdb carrying Gsk3a^tm1Jrw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsk3a Mutation: 18 strains or lines available

References

• Original: J:130033 MacAulay K, et al., Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell Metab. 2007 Oct;6(4):329-37
• All: 28 reference(s)