Gsk3a^tm1.1Jrw
Targeted Allele Detail

Summary

• Symbol: Gsk3a^tm1.1Jrw
• Name: glycogen synthase kinase 3 alpha; targeted mutation 1.1, James R Woodgett
• MGI ID: MGI:3771223
• Synonyms: Gak3a^-
• Gene: Gsk3a Location: Chr7:24927683-24937276 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Gsk3a^tm1.1Jrw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130033
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was removed by germ-line, cre-mediated recombination. The absence of protein product was confirmed by western blot analysis on brain, liver, spleen and testes extracts. (J:130033)

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsk3a Mutation: 18 strains or lines available

References

• Original: J:130033 MacAulay K, et al., Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell Metab. 2007 Oct;6(4):329-37
• All: 25 reference(s)