Esrrg^tm1Rev
Targeted Allele Detail

Summary

• Symbol: Esrrg^tm1Rev
• Name: estrogen-related receptor gamma; targeted mutation 1, Ronald M Evans
• MGI ID: MGI:3771320
• Synonyms: ERRgamma S-strain, Esrrg^-
• Gene: Esrrg Location: Chr1:187340988-187947082 bp, + strand Genetic Position: Chr1, 91.83 cM, cytoband H5
• Alliance: Esrrg^tm1Rev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129851
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neo cassette was inserted into exon 2 deleting the portion that encodes the DNA binding domain. The insertion produces a frame shift in the case of alternative splicing. The absence of a transcript and protein product was confirmed by RT-PCR and immunohistochemistry. (J:129851)

Expression

In Mice Carrying this Mutation:	25 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esrrg Mutation: 32 strains or lines available

References

• Original: J:129851 Alaynick WA, et al., ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab. 2007 Jul;6(1):13-24
• All: 8 reference(s)