Ptf1a^{tm2(cre/ESR1)Cvw}
Targeted Allele Detail

Summary

• Symbol: Ptf1a^{tm2(cre/ESR1)Cvw}
• Name: pancreas specific transcription factor, 1a; targeted mutation 2, Christopher VE Wright
• MGI ID: MGI:3771322
• Synonyms: Ptf1a^Cre-ERTM
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^{tm2(cre/ESR1)Cvw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180310
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Ptf1a^{tm2(cre/ESR1)Cvw} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ptf1a (MGI:1328312)

• Mutation details: RMCE using Ptf1a^tm1Mgn inserted a cre and mouse Esr1 (CreERTM) replacing exon 1 and 2 and a hygromycin resistance cassette downstream of exon 2. Flp-mediated recombination removed the FRT site flanked hygro cassette. (J:180310, J:194063)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ptf1a (mouse) Summary of all recombinase alleles driven by Ptf1a. Alliance mouse Ptf1a gene page

Tumor Data

List all tumor models in MMHCdb carrying Ptf1a^{tm2(cre/ESR1)Cvw}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 31 strains or lines available

References

• Original: J:180310 Kopinke D, et al., Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol. 2012 Feb 1;362(1):57-64
• All: 52 reference(s)