Slc40a1^tm1Nca
Targeted Allele Detail

Summary

• Symbol: Slc40a1^tm1Nca
• Name: solute carrier family 40 (iron-regulated transporter), member 1; targeted mutation 1, Nancy C Andrews
• MGI ID: MGI:3771547
• Synonyms: Fpn^null
• Gene: Slc40a1 Location: Chr1:45947228-45965683 bp, - strand Genetic Position: Chr1, 23.96 cM, cytoband B
• Alliance: Slc40a1^tm1Nca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129846
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo-cassette replaced exon 6 and part of exon 7 encoding amino acids 172 - 338 including 3 of the 10 predicted transmembrane segments. Immunohistochemical analysis confirmed the absence of protein in a subset of embryos from heterozygous crosses. (J:129846)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc40a1 Mutation: 54 strains or lines available

References

• Original: J:129846 Donovan A, et al., The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005 Mar;1(3):191-200
• All: 2 reference(s)