Cbll^{Tg(Alb-KL)7-2Mhos}
Transgenic Allele Detail

Summary

• Symbol: Cbll^{Tg(Alb-KL)7-2Mhos}
• Name: cerebelless; transgene insertion 7-2, Mikio Hoshino
• MGI ID: MGI:3771564
• Synonyms: cerebelless, Ptf1a^cbll
• Gene: Cbll Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Cbll^{Tg(Alb-KL)7-2Mhos} page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Cbll^{Tg(Alb-KL)7-2Mhos} involves 2 genes/genome features (4921504E06Rik, Otud1) View all
• Mutation details: A transgene insertion into chromosome 2 caused a nearby deletion event that disrupted the expression of several genes. A 313 kb deletion in chromosome 2 overlapped two genes, Otud1 and 4921522E24Rik, and disrupted the expression of a third upstream gene, Ptf1a. All three genes, which are normally expressed in the developing brain, had no expression in the cerebellum of E12.5 homozygotes. However, expression of Ptf1a in the pancreas was unaffected. The transgene that caused the deletion consisted of a mouse albumin enhancer and promoter fused to cDNA that encoded a secreted isoform of the human klotho gene. The transgene was expressed in the liver and the secreted protein was detectable in the serum of heterozygote mice. Mice homozygous for this transgene/deletion exhibit similar cerebellar defects as mice homozygous for a null allele of Ptf1a. (J:100997)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbll Mutation: 0 strains or lines available

References

• Original: J:100997 Hoshino M, et al., Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron. 2005 Jul 21;47(2):201-13
• All: 4 reference(s)