Arid5b^tm1Whit
Targeted Allele Detail

Summary

• Symbol: Arid5b^tm1Whit
• Name: AT-rich interaction domain 5B; targeted mutation 1, Robert H Whitson
• MGI ID: MGI:3771593
• Synonyms: Mrf-2^-
• Gene: Arid5b Location: Chr10:67928350-68114570 bp, - strand Genetic Position: Chr10, 35.14 cM, cytoband B5.1
• Alliance: Arid5b^tm1Whit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130390
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was replaced with a neo cassette. This exon encodes for the third and fourth helices of the ARID structure. The absence of trascript was confirmed by northern blot analysis on extracts from the heart. (J:130390)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arid5b Mutation: 136 strains or lines available

References

• Original: J:130390 Whitson RH, et al., Neonatal mortality and leanness in mice lacking the ARID transcription factor Mrf-2. Biochem Biophys Res Commun. 2003 Dec 26;312(4):997-1004
• All: 4 reference(s)