Pkd1^tm1.2Djmp
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm1.2Djmp
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1.2, Dorien JM Peters
• MGI ID: MGI:3771608
• Synonyms: Pkd1^del, Pkd1^del2-11
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm1.2Djmp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130079
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ-line. cre-mediated recombination results in the deletion of exons 2 through 11. The authors state that this is a null allele. (J:130079)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:130079 Lantinga-van Leeuwen IS, et al., Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet. 2007 Dec 15;16(24):3188-96
• All: 6 reference(s)