Pyy^tm1Mws
Targeted Allele Detail

Summary

• Symbol: Pyy^tm1Mws
• Name: peptide YY; targeted mutation 1, Mark W Sleeman
• MGI ID: MGI:3771716
• Synonyms: Pyy^-
• Gene: Pyy Location: Chr11:101997502-101998658 bp, - strand Genetic Position: Chr11, 65.48 cM
• Alliance: Pyy^tm1Mws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130105
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neo cassette was inserted after the translation initiation site in exon 1 and replaces the remaining exons. The lack of protein product was confirmed by immunohistochemistry of pancreatic islet cells. (J:130105)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pyy Mutation: 9 strains or lines available

References

• Original: J:130105 Wortley KE, et al., Peptide YY regulates bone turnover in rodents. Gastroenterology. 2007 Nov;133(5):1534-43
• All: 1 reference(s)