Pnrc2^tm1Shch
Targeted Allele Detail

Summary

• Symbol: Pnrc2^tm1Shch
• Name: proline-rich nuclear receptor coactivator 2; targeted mutation 1, Shiuan Chen
• MGI ID: MGI:3771820
• Synonyms: PNRC2^-
• Gene: Pnrc2 Location: Chr4:135598229-135601157 bp, - strand Genetic Position: Chr4, 68.01 cM, cytoband D3
• Alliance: Pnrc2^tm1Shch page

Pnrc2^tm1Shch/Pnrc2^tm1Shch mice have a lean phenotype

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130294
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with a neo cassette. The absence of transcript was confirmed by northern blot analysis on liver, spleen, kidney, brain, testes and uterus extracts. (J:130294)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnrc2 Mutation: 5 strains or lines available

References

• Original: J:130294 Zhou D, et al., Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity. J Biol Chem. 2008 Jan 4;283(1):541-53
• All: 1 reference(s)