Plagl2^tm1Wjmv
Targeted Allele Detail

Summary

• Symbol: Plagl2^tm1Wjmv
• Name: pleiomorphic adenoma gene-like 2; targeted mutation 1, Wim J M Van de Ven
• MGI ID: MGI:3771822
• Synonyms: PlagL2^-
• Gene: Plagl2 Location: Chr2:153069689-153083278 bp, - strand Genetic Position: Chr2, 75.41 cM, cytoband H2
• Alliance: Plagl2^tm1Wjmv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130260
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was preplaced with a lacZ and floxed neo cassette flanked by frt sites. Cre-mediated recombination was used to excise concatamers. The absence of the endogenous transcript and the presence of the fusion transcript was confirmed by RT-PCR on E16.5 and newborn mouse extracts. (J:130260)

Expression

In Mice Carrying this Mutation:	61 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plagl2 Mutation: 24 strains or lines available

References

• Original: J:130260 Van Dyck F, et al., Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007 Nov;6(5):406-13
• All: 2 reference(s)