Bcam^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Bcam^tm1Ics
• Name: basal cell adhesion molecule; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:3771876
• Synonyms: Lu^-
• Gene: Bcam Location: Chr7:19490063-19504457 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Bcam^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130191
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Duplication, Insertion
• Bcam^tm1Ics involves 1 genes/genome features (Bcam) View all
• Mutation details: A cassette containing the Agouti, 3'hprt and puro genes was inserted into intron 8 and resulted in a duplication of exons 2 through 8. The absence of protein product was confirmed by western blot analysis on kidney and intestine extracts. (J:130191)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcam Mutation: 35 strains or lines available

Notes

Insertion results in duplication of exons 2 through 8.

References

• Original: J:130191 Rahuel C, et al., Genetic inactivation of the laminin {alpha}5 chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse. Am J Physiol Renal Physiol. 2008 Feb;294(2):F393-406
• All: 2 reference(s)