Rgs13^tm1Drue
Targeted Allele Detail

Summary

• Symbol: Rgs13^tm1Drue
• Name: regulator of G-protein signaling 13; targeted mutation 1, Kirk M Druey
• MGI ID: MGI:3771964
• Synonyms: Rgs13^-
• Gene: Rgs13 Location: Chr1:144014392-144053110 bp, - strand Genetic Position: Chr1, 62.56 cM
• Alliance: Rgs13^tm1Drue page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130209
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a lacZ neo cassette. The absence of transcript in bone marrow-derived mast cells was confirmed by RT-PCR and the absence of protein in bone marrow-derived mast cells was confirmed by immunohistochemistry. (J:130209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rgs13 Mutation: 15 strains or lines available

Notes

ES cell line = iTL4 (129S6/SvEvTac)

References

• Original: J:130209 Bansal G, et al., Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13. Nat Immunol. 2008 Jan;9(1):73-80
• All: 1 reference(s)