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Trim24tm1Los
Targeted Allele Detail
Summary
Symbol: Trim24tm1Los
Name: tripartite motif-containing 24; targeted mutation 1, Regine Losson
MGI ID: MGI:3772050
Synonyms: Trim24L2
Gene: Trim24  Location: Chr6:37847746-37943231 bp, + strand  Genetic Position: Chr6, 17.07 cM, cytoband B1
Alliance: Trim24tm1Los page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130210
Parent Cell Line:  D4 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 4 was floxed by introducing a loxP site upstream of the exon and inserting a loxP flanked PGK/TK neomycin cassette downstream of the exon. Chimeric mice were generated, crossed with a Cre-deleter strain, and offspring were selected that had the neomycin selection cassette removed but left exon 4 intact. Genotypes were confirmed by genomic PCR. (J:130210)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Trim24tm1Los
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim24 Mutation:  99 strains or lines available
References
Original:  J:130210 Khetchoumian K, et al., Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet. 2007 Dec;39(12):1500-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory