Trim24^tm1.1Los
Targeted Allele Detail

Summary

• Symbol: Trim24^tm1.1Los
• Name: tripartite motif-containing 24; targeted mutation 1.1, Regine Losson
• MGI ID: MGI:3772051
• Synonyms: Trim24^-, Trim24^L-
• Gene: Trim24 Location: Chr6:37847746-37943231 bp, + strand Genetic Position: Chr6, 17.07 cM, cytoband B1
• Alliance: Trim24^tm1.1Los page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130210
• Parent Cell Line: D4 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4 was floxed by introducing a loxP site upstream of the exon and inserting a loxP flanked PGK/TK neomycin cassette downstream of the exon. Chimeric mice were generated, crossed with a Cre-deleter strain and offspring were selected that had both exon 4 and the neo selection cassette removed. The deletion was also predicted to generate a frameshift mutation with a premature stop codon. Gene inactivation was confirmed by Western blot analysis of liver and testis protein. (J:130210)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trim24^tm1.1Los

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim24 Mutation: 99 strains or lines available

References

• Original: J:130210 Khetchoumian K, et al., Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet. 2007 Dec;39(12):1500-6
• All: 4 reference(s)