Ahrr^tm1Yfk
Targeted Allele Detail

Summary

• Symbol: Ahrr^tm1Yfk
• Name: aryl-hydrocarbon receptor repressor; targeted mutation 1, Yoshiaki Fujii-Kuriyama
• MGI ID: MGI:3772082
• Synonyms: AhRR^-
• Gene: Ahrr Location: Chr13:74359237-74440450 bp, - strand Genetic Position: Chr13, 40.15 cM, cytoband C2
• Alliance: Ahrr^tm1Yfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130214
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and intron 2 were replaced with a lacZ cassette with a nuclear localization signal and a neo cassette. The absence of transcript upon induction with 3-methylcholanthrene was confirmed by RT-PCR analysis of spleen extracts. (J:130214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahrr Mutation: 33 strains or lines available

References

• Original: J:130214 Hosoya T, et al., Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice. Biochem Biophys Res Commun. 2008 Jan 18;365(3):562-7
• All: 2 reference(s)