Cldn6^{tm1(cre/ERT2)Dam}
Targeted Allele Detail

Summary

• Symbol: Cldn6^{tm1(cre/ERT2)Dam}
• Name: claudin 6; targeted mutation 1, Douglas A Melton
• MGI ID: MGI:3772092
• Synonyms: Cldn6^CIHV, Cldn6^{tm1(cre/ESR1)Dam}
• Gene: Cldn6 Location: Chr17:23898345-23901417 bp, + strand Genetic Position: Chr17, 11.99 cM
• Alliance: Cldn6^{tm1(cre/ERT2)Dam} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130142
• Parent Cell Line: AV3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Cldn6^{tm1(cre/ERT2)Dam} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cldn6 (MGI:1859284)

• Mutation details: The entire reading frame contained within exon 3 was replaced with the CIHV cassette that contains cre-ER, IRES, HIST2H2BE-Venus and a self-excising neo cassette. The absence of transcript was confirmed by in situ hybridization. This allele also functions as a reporter. (J:130142)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cldn6 (mouse) Summary of all recombinase alleles driven by Cldn6. Comparative matrix view of recombinase activities Alliance mouse Cldn6 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cldn6 Mutation: 20 strains or lines available

References

• Original: J:130142 Anderson WJ, et al., Genetic targeting of the endoderm with claudin-6(CreER). Dev Dyn. 2008 Feb;237(2):504-12
• All: 3 reference(s)