Trps1^tm1Ymur
Targeted Allele Detail

Summary

• Symbol: Trps1^tm1Ymur
• Name: transcriptional repressor GATA binding 1; targeted mutation 1, Yasuteru Muragaki
• MGI ID: MGI:3772098
• Synonyms: Trps1^-
• Gene: Trps1 Location: Chr15:50518148-50753859 bp, - strand Genetic Position: Chr15, 19.18 cM
• Alliance: Trps1^tm1Ymur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130140
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 and intron 3 were replaced with an IRES, lacZ and neo cassette. The absence of protein product was confirmed by immunohistochemistry on limbs of newborn mice. (J:130140)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trps1 Mutation: 64 strains or lines available

References

• Original: J:130140 Suemoto H, et al., Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Dev Biol. 2007 Dec 15;312(2):572-81
• All: 7 reference(s)