Lhx2^tm1.1Monu
Targeted Allele Detail

Summary

• Symbol: Lhx2^tm1.1Monu
• Name: LIM homeobox protein 2; targeted mutation 1.1, Edwin S Monuki
• MGI ID: MGI:3772172
• Synonyms: Lhx2^deltacKO
• Gene: Lhx2 Location: Chr2:38229293-38259745 bp, + strand Genetic Position: Chr2, 24.31 cM, cytoband B
• Alliance: Lhx2^tm1.1Monu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130167
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination was used to removal of exons 2 and 3. Authors state that this is a null allele. (J:130167)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx2 Mutation: 12 strains or lines available

References

• Original: J:130167 Mangale VS, et al., Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science. 2008 Jan 18;319(5861):304-9
• All: 2 reference(s)