Olr1^tm1Meht
Targeted Allele Detail

Summary

• Symbol: Olr1^tm1Meht
• Name: oxidized low density lipoprotein (lectin-like) receptor 1; targeted mutation 1, Jawahra L Mehta
• MGI ID: MGI:3772336
• Synonyms: LOX-1^-, LOX-1-KO, Olr1^tm1Saw
• Gene: Olr1 Location: Chr6:129462207-129484128 bp, - strand Genetic Position: Chr6, 63.35 cM
• Alliance: Olr1^tm1Meht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130794
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6, 7 and part of 8 were replaced with a neo cassette. The lack of transcript was confirmed by RT-PCR analysis and immunostaining of aortic tissues. (J:130794)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Olr1 Mutation: 33 strains or lines available

References

• Original: J:130794 Mehta JL, et al., Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res. 2007 Jun 8;100(11):1634-42
• All: 28 reference(s)