Bcat2^tm1.2Clyn
Targeted Allele Detail

Summary

• Symbol: Bcat2^tm1.2Clyn
• Name: branched chain aminotransferase 2, mitochondrial; targeted mutation 1.2, Christopher Lynch
• MGI ID: MGI:3772355
• Synonyms: BCATm^-, BCATm KO
• Gene: Bcat2 Location: Chr7:45219773-45239134 bp, + strand Genetic Position: Chr7, 29.36 cM
• Alliance: Bcat2^tm1.2Clyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129967
• Parent Cell Line: XSV1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 4 - 6, including multiple key active site residues. Protein expression is absent from the skeletal muscle, kidney, heart, brain, pancreas, and adipose tissue in homozygous mice. (J:129967)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcat2 Mutation: 193 strains or lines available

References

• Original: J:129967 She P, et al., Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007 Sep;6(3):181-94
• All: 6 reference(s)