Il13ra1^tm1Twy
Targeted Allele Detail

Summary

• Symbol: Il13ra1^tm1Twy
• Name: interleukin 13 receptor, alpha 1; targeted mutation 1, Thomas A Wynn
• MGI ID: MGI:3772443
• Synonyms: Il13ra1^-
• Gene: Il13ra1 Location: ChrX:35375763-35434912 bp, + strand Genetic Position: ChrX, 20.49 cM
• Alliance: Il13ra1^tm1Twy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130488
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a transmembrane lacZ cassette and a floxed neo cassette. The absence of transcript was confirmed by RT-PCR followed by endpoint PCR on lung fibroblasts. (J:130488)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il13ra1 Mutation: 19 strains or lines available

References

• Original: J:130488 Ramalingam TR, et al., Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat Immunol. 2008 Jan;9(1):25-33
• All: 17 reference(s)