Pafah2^tm1Arai
Targeted Allele Detail

Summary

• Symbol: Pafah2^tm1Arai
• Name: platelet-activating factor acetylhydrolase 2; targeted mutation 1, Hiroyuki Arai
• MGI ID: MGI:3772686
• Synonyms: Pafah2^-
• Gene: Pafah2 Location: Chr4:134123631-134154723 bp, + strand Genetic Position: Chr4, 66.68 cM
• Alliance: Pafah2^tm1Arai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130728
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 and 9 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on liver and kidney extracts. (J:130728)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pafah2 Mutation: 24 strains or lines available

References

• Original: J:130728 Kono N, et al., Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. J Biol Chem. 2008 Jan 18;283(3):1628-36
• All: 4 reference(s)