n-TUtca2^tm2Mym
Targeted Allele Detail

Summary

• Symbol: n-TUtca2^tm2Mym
• Name: nuclear encoded tRNA selenocysteine 2 (anticodon TCA); targeted mutation 2, Masayuki Yamamoto
• MGI ID: MGI:3772692
• Synonyms: Trsp^fl
• Gene: n-TUtca2 Location: Chr7:19035169-19035255 bp, + strand Genetic Position: Chr7, 9.56 cM
• Alliance: n-TUtca2^tm2Mym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130723
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed positive selection cassette (neomycin and thymidine kinase) was inserted downstream of the transcriptional unit and an additional loxP site was inserted upstream of the promoter elements. (J:130723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any n-TUtca2 Mutation: 2 strains or lines available

References

• Original: J:130723 Suzuki T, et al., Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2. J Biol Chem. 2008 Jan 25;283(4):2021-30
• All: 3 reference(s)