Kcnd3^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Kcnd3^tm1Dgen
• Name: potassium voltage-gated channel, Shal-related family, member 3; targeted mutation 1, Deltagen
• MGI ID: MGI:3772775
• Synonyms: Kv4.3^-
• Gene: Kcnd3 Location: Chr3:105359646-105581318 bp, + strand Genetic Position: Chr3, 46.32 cM, cytoband F3
• Alliance: Kcnd3^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130722
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv x C57BL/6
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 replaced with a lacZ-neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. (J:130722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnd3 Mutation: 62 strains or lines available

References

• Original: J:130722 Niwa N, et al., Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles. J Mol Cell Cardiol. 2008 Jan;44(1):95-104
• All: 8 reference(s)