Etv6^{tm3(NTRK3)Sho}
Targeted Allele Detail

Summary

• Symbol: Etv6^{tm3(NTRK3)Sho}
• Name: ets variant 6; targeted mutation 3, Stuart H Orkin
• MGI ID: MGI:3772780
• Gene: Etv6 Location: Chr6:134012663-134247121 bp, + strand Genetic Position: Chr6, 64.58 cM, cytoband G2
• Alliance: Etv6^{tm3(NTRK3)Sho} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130323
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo and stopper cassette along with the coding region of human NTRK3 from exon 6 with a polyadenylation signal was knocked into and replaced exon 6 and 7. The allele produces a fusion protein of the amino acids coded by the first 5 exons and protein tyrosine kinase domain of NTRK3. Expression of the fusion protein only occurs when the stopper cassette is removed by cre-mediated recombination. (J:130323)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Etv6^{tm3(NTRK3)Sho}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etv6 Mutation: 144 strains or lines available

Notes

This fusion product recapitulates the t(12;15)(p13;25q) translocation characteristic of human secretory breast carcinomas.

References

• Original: J:130323 Li Z, et al., ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 2007 Dec;12(6):542-58
• All: 3 reference(s)