Tg(Prnp-TBP*)71-16Xjl
Transgene Detail

Summary

• Symbol: Tg(Prnp-TBP*)71-16Xjl
• Name: transgene insertion 71-16, Xiao-Jiang Li
• MGI ID: MGI:3772866
• Synonyms: SCA17, TBP-71Q-16
• Transgene: Tg(Prnp-TBP*)71-16Xjl Location: unknown
• Alliance: Tg(Prnp-TBP*)71-16Xjl page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-TBP*)71-16Xjl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TBP (6908)

  Tbp	(MGI:101838)

• Mutation details: A transgenic construct containing the human TATA box binding protein, TBP, containing a 71 polyQ repeat expansion, under the control of the mouse prion protein promoter was injected into fertilized FVB/N mouse eggs. Founder line TBP-71Q-16 was established. The 71 polyQ-expansion is detected in the cerebral cortex and cerebellum by Western blot analysis. (J:130775)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:130775 Friedman MJ, et al., Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nat Neurosci. 2007 Dec;10(12):1519-28
• All: 5 reference(s)