Xist^tm4Sado
Targeted Allele Detail

Summary

• Symbol: Xist^tm4Sado
• Name: inactive X specific transcripts; targeted mutation 4, Takashi Sado
• MGI ID: MGI:3772876
• Synonyms: Xist^IVS
• Gene: Xist Location: ChrX:102503979-102526839 bp, - strand Genetic Position: ChrX, 46.15 cM, cytoband D
• Alliance: Xist^tm4Sado page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130425
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A splice donor and splice acceptor was inserted into exon 4. The absence of transcript expression was confirmed by RT-PCR. (J:130425)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xist Mutation: 8 strains or lines available

References

• Original: J:130425 Ohhata T, et al., Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification. Development. 2008 Jan;135(2):227-35
• All: 4 reference(s)