Ramp2^tm1.1Tash
Targeted Allele Detail

Summary

• Symbol: Ramp2^tm1.1Tash
• Name: receptor (calcitonin) activity modifying protein 2; targeted mutation 1.1, Takayuki Shindo
• MGI ID: MGI:3773019
• Synonyms: RAMP2^-
• Gene: Ramp2 Location: Chr11:101137160-101139076 bp, + strand Genetic Position: Chr11, 64.47 cM
• Alliance: Ramp2^tm1.1Tash page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130931
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were removed by germ-line, cre-mediated recombination. The absence of transcript was confirmed by RT-PCR. (J:130931)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ramp2 Mutation: 16 strains or lines available

References

• Original: J:130931 Ichikawa-Shindo Y, et al., The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest. 2008 Jan;118(1):29-39
• All: 9 reference(s)