Trim63^tm1Slbt
Targeted Allele Detail

Summary

• Symbol: Trim63^tm1Slbt
• Name: tripartite motif-containing 63; targeted mutation 1, Siegfried Labeit
• MGI ID: MGI:3773034
• Synonyms: MuRF1 KO
• Gene: Trim63 Location: Chr4:134042431-134056940 bp, + strand Genetic Position: Chr4, 66.58 cM
• Alliance: Trim63^tm1Slbt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130921
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 was replaced with a neo cassette with stop codons in all three reading frames. The absence of transcript was confirmed by RT-PCR. (J:130921)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim63 Mutation: 18 strains or lines available

References

• Original: J:130921 Witt CC, et al., Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. EMBO J. 2008 Jan 23;27(2):350-60
• All: 5 reference(s)