Kcnq1ot1tm4Tilg
Targeted Allele Detail
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Symbol: |
Kcnq1ot1tm4Tilg |
Name: |
KCNQ1 overlapping transcript 1; targeted mutation 4, Shirley M Tilghman |
MGI ID: |
MGI:3773036 |
Synonyms: |
Repdelta |
Gene: |
Kcnq1ot1 Location: Chr7:142766848-142850284 bp, - strand Genetic Position: Chr7, 88.15 cM
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Alliance: |
Kcnq1ot1tm4Tilg page
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Five evolutionarily conserved 30-bp repeated sequences in the proximal end of the transcript were deleted in a 657 bp region. A self-excising selection cassette was also placed downstream of the gene. After recombination and generation of chimeric mice, the selection cassette excised itself in the male germline leaving behind a single loxP site. Heterozygous mice that inherit the deletion paternally transcribe a truncated RNA that is missing the 657 bp of sequence but is otherwise a full length transcript.
(J:108700)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kcnq1ot1 Mutation: |
0 strains or lines available
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Original: |
J:108700 Mancini-Dinardo D, et al., Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev. 2006 May 15;20(10):1268-82 |
All: |
1 reference(s) |
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