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Kcnq1ot1tm4Tilg
Targeted Allele Detail
Summary
Symbol: Kcnq1ot1tm4Tilg
Name: KCNQ1 overlapping transcript 1; targeted mutation 4, Shirley M Tilghman
MGI ID: MGI:3773036
Synonyms: Repdelta
Gene: Kcnq1ot1  Location: Chr7:142766848-142850284 bp, - strand  Genetic Position: Chr7, 88.15 cM
Alliance: Kcnq1ot1tm4Tilg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108700
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsFive evolutionarily conserved 30-bp repeated sequences in the proximal end of the transcript were deleted in a 657 bp region. A self-excising selection cassette was also placed downstream of the gene. After recombination and generation of chimeric mice, the selection cassette excised itself in the male germline leaving behind a single loxP site. Heterozygous mice that inherit the deletion paternally transcribe a truncated RNA that is missing the 657 bp of sequence but is otherwise a full length transcript. (J:108700)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq1ot1 Mutation:  0 strains or lines available
References
Original:  J:108700 Mancini-Dinardo D, et al., Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev. 2006 May 15;20(10):1268-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory