Rgs7bp^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Rgs7bp^tm1Itl
• Name: regulator of G-protein signalling 7 binding protein; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:3773065
• Synonyms: R7BP^-, R7BP KO, Rgs7bp^tm1Igl
• Gene: Rgs7bp Location: Chr13:105082412-105191438 bp, - strand Genetic Position: Chr13, 56.9 cM, cytoband D1
• Alliance: Rgs7bp^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130903
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first two exons, including the start methionine, were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. (J:130903)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs7bp Mutation: 16 strains or lines available

References

• Original: J:130903 Anderson GR, et al., Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases. J Neurosci. 2007 Dec 19;27(51):14117-27
• All: 10 reference(s)