Tg(Nkx2-1-cre)2Sand
Transgene Detail

Summary

• Symbol: Tg(Nkx2-1-cre)2Sand
• Name: transgene insertion 2, Stewart Anderson
• MGI ID: MGI:3773076
• Synonyms: Nkx2-1BAC^Cre, Nkx2.1-cre, Nkx2.1^Cre, NKX2.1Cre, Tg(Nkx2-1-cre)1Qixu, Tg(Nkx2-1-cre)2Qixu, Ttf-1^Cre
• Transgene: Tg(Nkx2-1-cre)2Sand Location: unknown
• Alliance: Tg(Nkx2-1-cre)2Sand page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Nkx2-1-cre)2Sand expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkx2-1 (MGI:108067)

• Mutation details: A mouse BAC clone containing the Nkx2-1 gene was engineered to express cre recombinase. Fifteen base pairs at the 5'end of exon 2 of the Nkx2-1 gene were replaced with a cre-poly(A) construct. The mutated BAC clone was then used to generate transgenic mice. This construct is expressed in brain, thyroid, pituitary, and lung, with telecephalic expression first detectable at E10.5. (J:131144)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx2-1 (mouse) Summary of all recombinase alleles driven by Nkx2-1. Comparative matrix view of recombinase activities Alliance mouse Nkx2-1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

141 assay results 8 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Nkx2-1-cre)2Sand

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:131144 Xu Q, et al., Fate mapping Nkx2.1-lineage cells in the mouse telencephalon. J Comp Neurol. 2008 Jan 1;506(1):16-29
• All: 214 reference(s)