Pbx3^tm1Og
Targeted Allele Detail

Summary

• Symbol: Pbx3^tm1Og
• Name: pre B cell leukemia homeobox 3; targeted mutation 1, Stephen O'Gorman
• MGI ID: MGI:3773271
• Synonyms: Pbx3C
• Gene: Pbx3 Location: Chr2:34061469-34263154 bp, - strand Genetic Position: Chr2, 22.84 cM
• Alliance: Pbx3^tm1Og page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130927
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette with a 5' loxP site was inserted into intron 3 and an additional loxP site was inserted into intron 2. Targeting took place in PC3 ES cells, which are homozygous for Tg(Prm-cre)70Og, a cre transgene active only in haploid spermatids. A minority of the alleles created from this construct exhibited a deficiency of cre-mediated recombination driven by the male-germline specific protamine promoter in male germ cells and transmitted the conditional allele through male chimeric mice. (J:130927)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pbx3 Mutation: 35 strains or lines available

References

• Original: J:130927 Rottkamp CA, et al., Pbx3 is required for normal locomotion and dorsal horn development. Dev Biol. 2008 Feb 1;314(1):23-39
• All: 2 reference(s)