Traf6^tm2Ywc
Targeted Allele Detail

Summary

• Symbol: Traf6^tm2Ywc
• Name: TNF receptor-associated factor 6; targeted mutation 2, Yongwon Choi
• MGI ID: MGI:3773273
• Synonyms: Traf6^floxed
• Gene: Traf6 Location: Chr2:101508774-101532014 bp, + strand Genetic Position: Chr2, 53.9 cM
• Alliance: Traf6^tm2Ywc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85808
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin selection cassette was placed upstream of exon 7 and a STOP cassette followed by a loxP site and an YFP reporter were placed downstream of exon 7. Cre expression will remove the neo cassette, exon 7, and the stop sequence so that Traf6 expression is replaced with YFP expression. (J:85808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf6 Mutation: 34 strains or lines available

References

• Original: J:85808 Kobayashi T, et al., TRAF6 is a critical factor for dendritic cell maturation and development. Immunity. 2003 Sep;19(3):353-63
• All: 30 reference(s)