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Ightm1(VH558)Mss
Targeted Allele Detail
Summary
Symbol: Ightm1(VH558)Mss
Name: immunoglobulin heavy chain complex; targeted mutation 1, Mark S Schlissel
MGI ID: MGI:3773307
Synonyms: VH-KI
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130421
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA variable heavy chain gene segment belonging to the VH558 family along with 1.3 kb of upstream sequence and 500 bp of downstream sequence was knocked into a region of the IgH complex that lies 500 bp upstream of the most proximal D segment, DFL16.1. A loxP-flanked neomycin targeting cassette included in the targeting was subsequently removed by crossing chimeric mice with Cre expressing transgenic mice. Targeting events were confirmed through Southern blotting and restriction mapping. (J:130421)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:130421 Bates JG, et al., Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination. J Exp Med. 2007 Dec 24;204(13):3247-56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory