Scd1^tm2Ntam
Targeted Allele Detail

Summary

• Symbol: Scd1^tm2Ntam
• Name: stearoyl-Coenzyme A desaturase 1; targeted mutation 2, James M Ntambi
• MGI ID: MGI:3773308
• Synonyms: Scd1^lox
• Gene: Scd1 Location: Chr19:44382889-44396148 bp, - strand Genetic Position: Chr19, 37.98 cM
• Alliance: Scd1^tm2Ntam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130441
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 0.7 kb fragment encoding exon 3 was flanked 5' with a loxP site and 3' with a floxed neo cassette. No difference was detected in protein expression or activity in homozygous mice compared to wild-type mice. (J:130441)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scd1 Mutation: 24 strains or lines available

References

• Original: J:130441 Miyazaki M, et al., Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab. 2007 Dec;6(6):484-96
• All: 20 reference(s)